Design Project Articles Master Degree
Permanent URI for this communityhttps://hdl.handle.net/20.500.12475/48
Como parte de las Colecciones Especiales, la Biblioteca cuenta con los Artículos de Proyecto y Carteles de Investigación (Poster) sometidos para la obtención del grado de los estudiantes de la Escuela Graduada.
Recursos disponibles:
1. Artículos de Proyectos - 2008 en adelante.
2. Carteles de Investigación - 2018 en adelante.
Browse
19 results
Search Results
Item Statistical Analysis for the Development of a Mathematical Model for Liquid Phase Color Reproduction(Polytechnic University of Puerto Rico, 2009) Rodríguez Rivera, Wilson; Nieves Castro, Rafael A.Abstract - This study aims to develop a mathematical model, capable to give a receipt of the dies concentrations to be used to develop a desire color. The model helps to minimize, and in some cases eliminate, the trial and error technique. This study investigates the effect of the color coordinates vector such as L, a and b in order to evaluate if there exist a correlation by using the FD&C dies such as FD&C Yellow 5 FD&C Yellow 6, FD&C Blue 1 and FD&C Red 40. A 2k factorial experiment was performed, to identify those dies that have a significant effect within the color coordinates. Results obtained revealed that of the four FD&C studied, three of them have significant effect within the color coordinates. The FD&C dies used, showed a significant effect when is used alone or when are mixed. A correlation of the color coordinates and the factors was found. Three linear formulas were obtained from the L, a, and b vectors. Those formulas were introduced in a matrix model to developing or matching colors. Key Terms -Color space (L, a and B)[4], Lightness (L), a (position of green red axis), b (position of blue-yellow axis).Item Lean and Safe Manufacturing for an Antidepressant Tablets Coating Process(Polytechnic University of Puerto Rico, 2009) Torres Santiago, Meraris; Zárate, PatriciaAbstract - The Lean and Safe Manufacturing Process (6S event) was selected for implementation in an antidepressant tablets coating manufacturing process. The coating process was identified due to the utilization of toxic ingredients and hazardous materials during the coating solution preparation and during the coating application. In addition, lost time and productivity were identified in the process. The tool selected to perform a Lean and Safe Manufacturing Process in this coating process was 6S (Sort, Set in Order, Shine, Schedule, Score and Safety). Contributions, like the creation of a system that will be used to maintain an organized, clean, safe, and efficient setting that enables the highest level of value-added performance, were achieved during the 6S event implementation. In addition, a decrease in cycle time, in operators needed in the process execution, and minimization of injuries risk, were very important contributions achieved. Key Terms - 6S, Coating Process, Lean and Safe Manufacturing, Manufacturing Process.Item Estudio de los Aspectos Ergonómicos en Laboratorios de Control de Calidad en Industrias Farmacéuticas(Polytechnic University of Puerto Rico, 2009) Figueroa Colón, Marielis; Pabón González, MiriamAbstracto - El objetivo de esta investigación es conocer, cuan efectivo son los diseños ergonómicos en laboratorios de control de calidad de las industrias farmacéuticas. En esta investigación se realizó una evaluación de los diseños ergonómicos en laboratorios de Control Calidad en industrias farmacéuticas. Se realizó un análisis cualitativo y un análisis cuantitativo. El análisis cualitativo consistió en una encuesta. Se entregó un cuestionario a 32 empleados de laboratorios de control de calidad de dos industrias farmacéuticas. En el análisis cuantitativo se diseñaron planos de piso donde se estudió la organización del laboratorio. También se estudiaron aspectos ambientales tales como iluminación y temperatura. Luego de evaluar y comparar cada uno de los análisis se llegó a la conclusión que el diseño ergonómico en los laboratorios de control de calidad en las farmacéuticas no son muy efectivos. Por tal razón, se efectuaron una serie de recomendaciones relacionadas a cada una de las áreas estudiadas. Obteniendo de esta manera empleados que se sientan más cómodos en sus áreas de trabajo, produciendo así un trabajo de mayor calidad y productividad.Item Quality Improvement in a Medical Device Manufacturing Process Applying Six Sigma Tools(Polytechnic University of Puerto Rico, 2009) Rondón Nieves, Luis Daniel; Zárate, PatriciaAbstract - The current manufacturing process of a medical device product has great opportunities on scrap percent reduction, which has been impacting the material and labor costs of the product, as well as in defects per million (DPMs) reduction, to improve the quality of this product. The current scrap percent has been affecting the production yield and complaints from clients (surgeons) have been increasing during the last Fiscal Year. The Six Sigma structure DMAIC: Define, Measure, Analyze, Improve, and Control, will be the key for the success of this project. The expected benefits are the evaluation, recommendation, and implementation of any opportunity of quality improvement that results in a positive impact to the clients at a low cost of production for the company. The main research contribution is that this project provides the customers (surgeons and their patients) an instrument that always actuate as established in the specifications to save humans lives. Key Terms Medical Devices, Process Optimization, Quality Improvement, Six Sigma.Item Anticipando la Crisis(Polytechnic University of Puerto Rico, 2009) Blanco Colón, Luis A.; Ramírez, JuanAbstracto - Este proyecto tiene como meta orientar sobre los objetivos necesarios que una empresa debe establecer, para implementar un plan de contingencia para evitar interrupciones parciales o prolongadas de sus actividades de negocio. En el ambiente riesgoso y competitivo en que vivimos, muchas empresas están optando por establecer planes de continuidad de negocio, para mejorar su habilidad de responder o mitigar estas interrupciones. Este plan es una herramienta que permite a las empresas reconocer sus vulnerabilidades, e implementar procesos que le permitan responder de manera eficiente para mantener operando a una empresa, antes, durante o después de un desastre o evento que pueda afectar sus operaciones de negocio.Item Comparación de Eficiencia en Cuanto a Comportamiento y Costo Entre el Diseño ASD y LRFD para el Edificio UNILOPEZ(Polytechnic University of Puerto Rico, 2009) Veras Meléndez, Leonardo; Guzmán De La Cruz, Alberto L.Abstracto - Este documento consistió en el análisis estructural del edificio de oficinas UNILOPEZ (estructura de acero), mediante el uso de un programa de computadoras llamado ETABS, el cual se especializa en el análisis y diseño interactivo de edificaciones. Se consideraron los códigos UBC 97 y ASCE 7-02. Dos diseños por separado fueron realizado tomando el criterio LRFD y ASD provenientes del AISC 13ra Edición. Mediante los resultados obtenidos se determinó que el diseño utilizando el criterio ASD presentó un incremento de aproximadamente 14% mínimo en el costo de la estructura y diferencias de desplazamientos entre un piso y otro, que fluctuaron entre un 2% y un 78% más (ver Tabla 5) en relación a los resultados obtenidos al usar el criterio LRFD. Términos Claves - Allowable Strength Design, American Institute of Steel Construction, Estructuras de Acero, Load and Resistance Factor Design.Item Development of Vaporized Hydrogen Peroxide (VHP) Decontamination Cycle for a Syringe Isolator(Polytechnic University of Puerto Rico, 2009) Ruiz Vargas, José J.; Pabón González, MiriamAbstract - A parenteral syring filling line inside a closed cabin isolator was installed in an existing manufacturing space. To increase sterility assurance the isolator must be effectively biodecontamined by means of Vapor Hydrogen Peroxide (VHP) to provide a minimum of 6 log-reductions and a residual concentration of VHP of less than 1ppm. During the cycle development phase the operating characteristic and parameters for the decontamination were tested and optimized following the proposed methodology in this article. Final adjustment of the injection quantities was based upon results of the worst case biological indicator tests performed during the study. Based on the results, parameters and validation testing were established to provide for complete destruction of all biological indicators. Key Terms - H2O2 decontamination, cycle development, biological indicator (BI), chemical indicator (CI)Item Piedras Blancas Landslide: Mitigation Works(Polytechnic University of Puerto Rico, 2009) Rendón Ferrer, Janet; Collazos, OmairaAbstract - The Puerto Rico Highway and Transportation Authority has conducted since the 1980s several geotechnical investigations about the Piedras Blancas Landslide in the Municipality of San Sebastian. This landslide has brought damages during various decades, presenting cracks and sinking of the highway PR-111, and settlements of nearby residences and commerce. The failure area has a creek, a natural depression pond, a springs’ history, and a sensitive geology, San Sebastian Formation. Also, it is bounded uphill by the Lares Escarpment, a high limestone cliff rich in sinkholes. Through this paper it is possible to appreciate a number of contributing factors that could trigger this landslide and then take care of it through a gabion terraces design. This proposal deals with the topographic and hydrologic impacts to the terrain produced by fill and cut construction works. Soil survey information comes from Puerto Rico Highway and Transportation Authority (PRHTA) reports. Key Terms - back analysis, colluvium, gabions, landslide.Item Development of General Guidelines for the Pharmaceutical Manufacture Company Reaction to a Consent Decree Emitted by the Federal Drug Administration (FDA)(Polytechnic University of Puerto Rico, 2009) Pérez Moyeno, Janet; Nieves Castro, Rafael A.Abstract ⎯ Consent Decrees have been very popular lately. The consent decree mandates that a company start initiating change, and that change is usually associated with the way the company is manufacturing a product; and, it will involve the company re-constitute the manufacturing practices to bring it in alignment with the Food and Drug Administration (FDA’s) Good Manufacturing Practices. This project main purpose is to give guides on how pharmaceutical industries should react when a Consent Decree is given. Based on all information gathered from different sources, the consequences that bring the consent decree, the review of FDA inspectional process, and the hints required to effectively interact with the FDA are given. Finally, the guide will assist the companies to manage important events regarding compliance with the Good Manufacturing Practices and with the requisites of the consent decree. Key Terms ⎯ cGMP, consent decree, FDA inspections, regulatory issues, warning letters.Item Application of Design of Experiment to Demonstrate Equivalency of Two Multi Layer Compression Process for an Extended Release Tablets Product(Polytechnic University of Puerto Rico, 2009) Carrión Vega, Jaime; Nieves Castro, Rafael A.Abstract ― A design of experiment (DOE) was performed to a multi layer compression process that is going to be transferred from facility A to facility B. This study demonstrates and compared the equivalence of the compression process of a non-validated process site with a validated process from the original site. The relevance of this project is to demonstrate the equivalence of the process to ensure the robustness, and quality of the product. During the compression process, the weight of multiple stages, thickness, and hardness were collected in both machine. The data collected was analyzed using One-Way-ANOVA and Kruskal-Wallis test. Based on the results obtained from the data, it was concluded that both multi layer compression process are equivalent. Key Terms ― Design of Experiment, Extended Release Tablets, Multi Layer Compression Process, One – Way – ANOVA.