Communities in PRCR
Select a community to browse its collections.
- Colecciones de la Albizu University
- Colecciones digitales de Atenas College
- Colecciones de los Centros Sor Isolina Ferré
- Materiales utilizados para la certificación.
Recent Submissions
Understanding Genomic Sequencing Workflows Through Data-Driven Analysis and Pilot Design
(Polytechnic University of Puerto Rico, 2026) Rodríguez Rosario, Claudia A.; Pabón González, Miriam
This study developed and designed a data-driven process improvement pilot for COVID-19 genomic sequencing at the Research Institute of the Puerto Rico Science, Technology & Research Trust, based on workflow mapping and analysis. The workflow includes key stages such as RNA extraction, library preparation, sequencing, and bioinformatics analysis, where variability can propagate across interconnected processes and impact overall performance. A data-driven case study approach was used, combining qualitative and quantitative analysis to evaluate operational performance over a three-month period. Key metrics analyzed included first-pass yield, rework rates, and turnaround time, providing visibility into workflow inefficiencies and performance gaps. Based on this analysis, the study develops a structured framework to identify sources of variability and proposes a data-driven pilot design to evaluate potential process improvements in a controlled environment. This work bridges the gap between process analysis and implementation planning in laboratory environments.
Implementation of a Visual Scheduling and Booking System for a Shared Recipe Development Unit Using Lean Methodology
(Polytechnic University of Puerto Rico, 2026) Rivera Mercado, Keyshla M.; Morales Morales, José Alberto
This project focuses on improving the management of shared laboratory resources in Lab 1701 of a biopharmaceutical manufacturing site through the implementation of a visual scheduling and booking system. The objective was to increase visibility, reduce administrative burden, and improve coordination for the use of the Recipe Development Unit and sample management activities. Lean methodology was applied, including Voice of the Customer analysis and Value Stream Mapping, to evaluate the current state and design a future-state process supported by visual management and standardized work. A Smartsheet-based booking dashboard was developed and piloted with 40 laboratory users. Survey results demonstrated improved user satisfaction. Administrative processing time was reduced by approximately 60%. Statistical validation showed that, at a significance level of α = 0.05, the observed reduction was not significant due to limited sample size and high process variability, indicating the need for additional data collection to confirm long-term process improvement.
Optimización del Proceso Analítico en el Laboratorio Ambiental X para el Equipo Mufla: Reducción de Tiempo y Controles de Seguridad
(Polytechnic University of Puerto Rico, 2026) Díaz Torres, Lariann M.; Nieves Castro, Rafael A.
El laboratorio ambiental X enfrenta retrasos en los resultados analíticos de los procedimientos que requieren la prueba de combustión, ya que la mufla opera fuera del horario laboral. Además, existe el riesgo de exposiciones a gases nocivos como CO entre otros, al personal, debido a que son liberados en un sistema de ventilación cerrado. Para solucionar este evento, se desarrolló el proyecto con el objetivo de implementar un sistema de extracción eficiente que transfiera los gases liberados al exterior del laboratorio. El método DMADV se aplicó para seleccionar un extractor apropiado. La implementación de un ventilador dedicado a la mufla que extrae los gases de combustión durante las horas laborables acorta los periodos laborales y restablece la salud del personal. También, cumple con las regulaciones estatales y federales. Valorando tres cotizaciones, se sugirió el Hood Sentry Air System por su eficiencia en calidad, capacidad, costo y seguridad laboral.
“Lean Manufacturing” Aplicado a un Taller de Diseño de Moda: Optimización del Espacio y del Flujo de Trabajo en un Entorno Educativo
(Polytechnic University of Puerto Rico, 2026) Cortés Burgos, Laura del Sol; Nieves Castro, Rafael A.
Este estudio examina la implementación de la metodología “Lean Manufacturing” en un taller de diseño de moda de nivel de escuela superior, con el objetivo de mejorar la organización del espacio, reducir desperdicios de movimiento y optimizar el flujo de trabajo académico. A partir de un diagnóstico inicial, se identificaron problemáticas asociadas a la desorganización del entorno, la dispersión de herramientas y la ausencia de un flujo de trabajo estructurado. Se adoptó un enfoque mixto con diseño de investigación-acción, integrando herramientas Lean como 5S, mejora en la distribución del espacio físico, control visual y estandarización de procesos. Los resultados obtenidos reflejan una reducción del tiempo de búsqueda de materiales de 15 a 5 minutos por sesión, así como una disminución del tiempo perdido por desplazamientos innecesarios equivalente al 6.5% del tiempo de clase. Los hallazgos sugieren que la aplicación de Lean en contextos educativos no solo mejora la eficiencia operativa, sino que también transforma la dinámica del aprendizaje práctico.
Regulatory Frameworks, Licensing Requirements, and Drug Accessibility: Challenges in Puerto Rico Related to Innovative Treatments for Chronic Depression
(Polytechnic University of Puerto Rico, 2026) Ruiz Quiñones, Luwairy; Pabón González, Miriam
This study examined how licensing requirements, certifications, and regulatory frameworks influence drug pricing and access to innovative treatments in Puerto Rico, using TRANQUI-Spray (a fictitious name used for confidentiality purposes), a Risk Evaluation and Mitigation Strategy (REMS)-mandated, controlled-substance nasal spray for treatment-resistant depression as the central case study. The research analyzed how intellectual-property protections and complex approval pathways shape market dynamics, limit competition, and contribute to high medication costs. It also evaluated how FDA and DEA regulations, REMS infrastructure, and clinical certification requirements restrict the availability of novel therapies for chronic diseases. Through a qualitative approach, the study identified structural barriers to equitable access and highlighted opportunities for regulatory simplification, expanded REMS-certified capacity, and improved policy alignment. Findings underscore the need for streamlined processes that reduce administrative burden, support generic entry, and enhance affordability, ultimately promoting better health outcomes and strengthening Puerto Rico’s healthcare system.