Optimizing Automated Clean-In-Place Operations to Increase Productivity in a Biotechnology Manufacturing Plant

Abstract

Automated Clean-In-Place Operations are an essential part of the manufacturing operations by ensuring a clean state of the equipment and/or transfer lines. However, during a voice of the customer (VOC) and value-added activities assessment, it was determined that some equipment surfaces were only exposed to salts solutions that were easy to remove. During these observations, it was evident that the clean-in-place operations needed to be optimized to increase productivity. Cleaning cycle optimization was performed under a characterization study that confirmed the effectiveness of the optimized cleaning cycle for non-product contact equipment and/or transfer lines. The optimization consisted of several rinses with purified water and a final rinse with hot water for injection (WFI). Automated recipes were modified to prevent the use of aggressive cleaning agents and/or recirculation's in the cleaning operation. The optimization of the cleaning operations increased productivity by hard savings in detergents and a significant cycle time reduction. Key Terms - Automation, Cleaning, Clean-inPlace, Cycle Time, Productivity, Savings, Water for Injection (WFI).