Manufacturing Competitiveness
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12475/52
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Item Evaluation of Reagents Used in Solution Preparation to Reduce Reworks in Research and Development Laboratories(Polytechnic University of Puerto Rico, 2019) Quiñones Rodríguez, Wilmer; Nieves Castro, Rafael A.Research and development laboratories are working with improvements and discovery of new drugs. As part of their activities, they need solutions such as Buffers and Mobile Phases for analytical testing. It was found that a main reason that increase rework in solutions preparations is the unavailability of reagents. Looking for reagents for solution preparation with the correct purity grade and specifications is the main goal they face. Evaluating reagents, purchasing and establishing a tool for reagent reorder will reduce significantly rework and waste generated due to incorrect reagent used. Key Words ⎯ Purity Grade, Reagent Inventory, Solution Preparation, Waste Reduction.Item Implementation of the 5S Methodology in the Spare Parts Warehouse Area located in a Medical Device Company(Polytechnic University of Puerto Rico, 2019) Rosado Miranda, John; Pons Fontana, Carlos A.The implementation of a continuous improvement and application of the 5 ́S in a medical device company was specifically developed in the warehouse area (spare parts) and focused on the identification of materials, order and cleaning in order to achieve Certification of the ISO 9001: 2000 Quality Platform referring to quality and good customer service. The main objective of this project was to carry out inspections in the area of the warehouse to observe the existing deficiencies and improve them based on the 5 ́S and Kaizen methodology applied to the warehouse. Key Terms ⎯ 5S Methodology, Continuous Improvement, Kaizen, ISO 9001: 2000 Quality Platform.Item Implementación de un Sistema de Control de Inventarios en el Almacén de Mantenimiento de un Complejo de Apartamentos(Polytechnic University of Puerto Rico, 2019) Córdova Morales, Ivania Z.; Morales, José A.Este estudio propone un sistema de control de inventario que mejora la gestión de compras y organización de artículos de mantenimiento para el complejo de apartamentos. Específicamente: (1) diagnosticar el proceso de gestión del inventario del almacén, (2) aplicar el método ABC para clasificar el inventario de artículos por importancia de utilización y valor para facilitar su almacenamiento en el almacén, (3) definir estrategias de gestión de inventario que incluya cantidad óptima a pedir, política de pedidos con el Modelo EOQ y políticas de revisión de existencia para cada clasificación ABC que mejoren el manejo del inventario y (4) proponer mejoras en el proceso de gestión del almacén donde incluya la distribución física, procedimientos y caracterización de los artículos del almacén mediante la utilización de la herramientas Metodología 5S y Gestión Visual. Los resultados reflejaron exitosamente la implementación de un sistema de control de inventario en donde se obtuvo: la clasificación ABC del inventario por valor de utilización, las cantidades óptimas a ordenar para los artículos dentro de la clasificación A, políticas de inventario para estos y hasta la organización y ahorro de espacio del almacén mediante un nuevo diseño del mismo utilizando la clasificación ABC. Términos claves ⎯ Gestión Visual, Método ABC, Metodología 5S, Modelo EOQ.Item Mejorar la Eficiencia en el Laboratorio Químico de una Farmacéutica a través de Aplicaciones de Metodología de Calidad(Polytechnic University of Puerto Rico, 2019) Berríos Rodríguez, Damián; Nieves Castro, Rafael A.Los laboratorios son de suma importancia, no solo en las escuelas y universidades; también lo son para las investigaciones y las farmacéuticas. Estos son los encargados de asegurar la calidad de sus productos. Los laboratorios químicos de las farmacéuticas tienen la oportunidad de alcanzar niveles óptimos. El objetivo de este proyecto es lograr un rendimiento perfecto, cero defectos, que los recursos puedan optimizarse, reducir los tiempos y una mejor satisfacción al cliente, utilizando la metodología de Six Sigma, DMAIC y 5S. En este proyecto se pudo demostrar que el diseño de las metodologías 5S y DMAIC es efectivo en los laboratorios. Sus resultados fueron visibles en la organización, ya que hubo reducción de tiempo y estrés entre los analistas. Estas metodologías traen cambios a gran escala con mayor producción y crecimiento de la farmacéutica, pero se necesita su seguimiento, evaluación y estudio constante para que su efectividad sea duradera. Términos Claves – DMAIC, Eficiencia, Six Sigma, 5S.Item Lean Six Sigma Application to reduce cycle time in the waiting process for medical attention in patient with green categorization in adult emergency area in Hospital X(Polytechnic University of Puerto Rico, 2010) Burgos Frontanés, Samuel J.; Rodríguez, JoséThe service area is one of the healthcare industries area that are in continuous search to optimize their process in order to provide a quality service to their customer (patient). In order to provide a total to quality service and reduce variable and eliminate waste in their process, many healthcare industries adopt the implementation of Lean Six Sigma methodology in their process. The Lean Six Sigma methodology is a useful tool based on maximizing value and minimizing waste. The design project focus in the implementation of lean six sigma tools from the Triage until medical treatment in the adult emergency department in order to reduce the variables and waste that make the waiting time process to be medical treated extended. This implementation aims to reduce the waiting cycle time in a 25% at the same time it seeks to eliminate the patient drains from the waiting area. Key Terms– Healthcare, Lean Six Sigma, Emergency DepartmentItem Process Optimization by Implementing Lean Six Sigma in an Optical Manufacturing Laboratory(Polytechnic University of Puerto Rico, 2010) Arbona Arroyo, Carolina Marie; Pons Fontana, Carlos A.The Design Project intends to be implemented in an Optical Manufacturing Laboratory. This laboratory is located at Mayagüez with the purpose of distributing ophthalmic lenses to different optical centers around the island as well as different ophthalmologists in the west area. After some weeks of research investigation it has been noticed that the laboratory is resulting in scraps, work tools are not accessible, inventory is not well organized, and orders are not being delivered within the time period. In this project Lean Manufacturing tools as well as DMAIC and/or Six Sigma tools will be implemented along with some recommendations to help the laboratory improve its processes. Some of the Lean / Six Sigma tools used will be the Cause and Effect Diagram, Work Standardization, Pareto Chart, and the 5S Methodology. At the end of this project it is expected to be reduced by 0.7% (from 1.7%) the scraps manufactured, improve quality and overall efficiency. Key Terms - laboratory, lean manufacturing, optical manufacturing, six sigma.Item The Effect of the Vaporized Hydrogen Peroxide Residues in a Trypticase Soy Agar Plates for a New Barrier Isolated Syringe Filling Machine(Polytechnic University of Puerto Rico, 2011) Lebrón Santos, Ana Delma; Nieves Castro, Rafael A.This study has been performed to evaluate the feasibility and adequacy of the Trypticase Soy Agar (TSA) plates in promoting growth after being exposed to Vapor Phase Hydrogen Peroxide (VPHP) decontamination cycle. This project has been successfully completed in two phases. Data obtained from Phase 1 demonstrated that the growth promotion properties of the Becton & Dickinson Sterile Triple bagged of TSA plates were not impacted after being exposed to up to three consecutive decontamination cycles in the new syringe filling line isolator at the established decontamination cycle parameters. The results obtained from Phase 2 as well demonstrates no impact in the growth promotion properties after being exposed to a decontamination cycle, unpacked and the individual plates exposed to 1 ppm VPHP residues up to two (2) hours in a simulated manufacturing process when using the Quality Control Work Center isolator. Key Terms - isolator decontamination cycles, Trypticase Soy Agar plates, vapour phase hydrogen peroxide.Item Use of Experimental Design for the Characterization of a Depyrogenation Machine(Polytechnic University of Puerto Rico, 2010) Cabrera, Migdalis; Torres, EdgarDepyrogenation tunnel are used in pharmaceutical filling lines to sterilize glass containers before they are aseptically filled. These tunnels use unidirectional hot air at temperatures up to 350°C and can be used to sterilize and depyrogenated glass vials and glass containers. The experimental design presented in this project describes the performance qualification activities process in the dry heat depyrogenation tunnel at worst case conditions ensuring the integrity of the HEPA filters. The parameters considered were: belt speed, temperature and endotoxin reduction. The parameters identified after analyzing the measurement are to be improved by applying DMAIC methodology from Six Sigma. Key Terms - DMAIC, experimental design, performance qualification, HEPA filters.Item Evaluation of the Effects of Gas Plasma test in a Tangential Flow Filter(Polytechnic University of Puerto Rico, 2013) Calo, David; Pesante Santana, José A.In this article you will see the combination of two technologies that produce an efficient product. One of the productions of the new form is the separation and filtration combined by retaining a plasma gas treatment. This treatment is to change the polarization of the filter making the filtration more efficient. This type of filter is used to separate abase molecule of its size. The plasma gas applied to the filter changes the condition producing an efficient filtration. It takes three different exposure times and the filter as a standard will define the flow and pressure of Diafiltration. The flow is measured in a define pressure by a control filter establishing and comparing it with other filters to see which is the suitable time for the plasma gas exposure and that does not affect the filter. The elapse of time has been identified as the most effective and adequate increasing the flow and the exposure time. Key Terms-Diafiltration, Gas Plasma and excellent performance.Item The Increase of Machine Utilization, using SMED, a Lean Manufacturing Tool(Polytechnic University of Puerto Rico, 2013) Herrero, Ramón V.; Torres, EdgarIn this project we will see the application of SMED (Single Minute Exchange Dye) a Lean Manufacturing tool in the Medical Device Industry, and how it helps to reduce the time of changeover in a machine. One of the benefits of this tool is to help manufacturing to increase the OEE (Overall Equipment Effectiveness) of the machine thru the increase in utilization. Key Terms - Changeover, DMAIC, Lean Manufacturing, SMED.