Implementing Six Sigma Tools to Reduce Formulation Errors in a Compounding Pharmacy

Abstract

Formulation errors are medication errors that occur when a prescribed mixture is not performed as per the required medical order. Formulation errors in compounded total parenteral nutrition units represent an inherent risk to the safety of the intended patient. A 46.43% increase in the metrics incidence associated with formulation errors was identified in a patient-specific compounding pharmacy. This project aimed to comprehend the effects of implementing six sigma tools in the compounding pharmacy's order entry process by focusing on reducing the incidence of the metrics associated with formulation errors by 50%. By applying the DMAIC methodology, the incidence in the metrics of formulation errors has been reduced, thus reducing the number of formulation non-conformances and external complaints. Key Terms ⎯ Compounding Pharmacy, Formulation Errors, Process Improvement, Six Sigma.